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KMID : 1146920210510020213
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Journal of Pharmaceutical Investigation
2021 Volume.51 No. 2 p.213 ~ p.222
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Development of a zero-order kinetics drug release floating tablet with anti?flip-up design fabricated by 3D-printing technique
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Huanbutta Kampanart
Sriamornsak Pornsak
Kittanaphon Thanayoth
Suwanpitak Kittipat
Klinkesorn Natdanai
Sangnim Tanikan
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Abstract
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Purpose: Helicobacter pylori is a common cause of peptic ulcer disease, but patient’s low compliance to treatment can cause antibiotic resistance. The aim of the study was to describe a gastroretentive drug delivery system using an anti?flip-up floating tablet design prepared by using 3D printing with the goal of achieving better therapeutic outcomes.
Methods: Polylactic acid (PLA) was the printing material for the floating tablet housing, with metronidazole as the model drug. The core tablet was prepared by direct compression and placed in the middle of the housing. The floating system was optimized by using a Box?Behnken experimental design with core tablet main factors of drug release orifice, air volume (height was varied), and compression force. The optimized formulation was prepared to test the prediction efficiency of the model.
Results: The optimized model required a drug release orifice of 23.10 mm2, air compartment height of 2.0 mm, and compression force of 3.63 tons, providing constant drug release for 8 h (average R2?=?0.9920). The optimized anti?flip-up tablets did not flip-up during the test.
Conclusion: This gastroretentive drug release model shows possibility for constant extended drug dissolution which could enhance therapeutic efficiency of peptic ulcer disease from Helicobacter pylori.
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KEYWORD
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Floating drug delivery systems, 3D-printing, Zero-order kinetics drug release, Helicobacter pylori
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